Study Goal

The goal of the study was to evaluate the efficacy of the oral insulin (100 units) in combination with failing oral agents to control post-prandial glucose in Type-2 diabetic patients after standard meal challenges at breakfast, lunch and dinnertime

Method

• Crossover study
  
• CGMS sensor placed subcutaneously prior to commencement of study
  
• Day One - administer oral insulin (100 units) via the RapidMist device in combination with oral tablets with each meal
  
• Day Two – administer oral hypoglycemic agents only with each meal
  
• Measure blood glucose with MiniMed CGMS sensor

Results

Conclusions

• Oral Insulin taken at meal times was associated with a significantly lower postprandial glucose rise (9% vs 27%, p<0.001) when compared with their oral agents alone
  
• Oralin can be used effectively with failing oral agents as an add-on therapy to achieve better control on meal related glucose rise and avoid future diabetic complications

Introduction | Abstract |
Oral Insulin Spray | Study Goal, Method, Research, Conclusions